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(A,B) Hypothesized pattern of viral escape and reversion to wild type (WT) in pair 124. CD8 T cell responses to the HLA-B18-restricted CMV epitope NEIH. (A) Viral mutation (or “escape”) in the presence of maternal CD8 T cell response to wild type epitope resulting in loss of anti-WT response. (B) Viral reversion to WT in the absence of fetal CD8 T cell response to mutant epitope resulting in gain of anti-WT response.
