Table 3.
Demographic, behavioral, and clinical characteristics in the total sample of people with HIV by cognitive profile.
| Profile 1 | Profile 2 | Profile 3 | ||
|---|---|---|---|---|
|
Unimpaired (n = 618) n (%) |
Relatively weak auditory attention and episodic memory (n = 461) n (%) |
Global weaknesses (n = 587) n (%) |
P-value | |
| Age, M (SD) | 41.2 (9.1) | 39.4 (9.4) | 44.2(10.2) | <0.001 |
| Male | 544 (88) | 401 (87) | 520 (89) | 0.73 |
| Years of education, M (SD) | 13.5 (2.5) | 12.9 (2.7) | 13.5 (2.8) | <0.001 |
| WRAT-4, M (SD) | 102.2 (11.9) | 96.5 (13.6) | 97.6 (14.2) | <0.001 |
| Race | <0.001 | |||
| White | 387 (63) | 202 (44) | 382 (65) | |
| Black | 119 (19) | 104 (23) | 91 (15) | |
| Hispanic | 76 (12) | 132 (29) | 91 (15) | |
| Other | 36 (6) | 23 (5) | 23 (4) | |
| IADL dependence | 2.2 (2.7) | 2.2 (2.7) | 3.0 (3.1) | <0.001 |
| BDI-II | 12.4 (9.9) | 13.4 (10.8) | 14.7(10.4) | <0.001 |
| DSM-IV (CIDI) diagnoses | ||||
| MDD | ||||
| Current | 67 (17) | 59 (16) | 98 (22) | 0.06 |
| Lifetime | 198 (51) | 154 (43) | 220 (50) | 0.05 |
| Alcohol (current or lifetime*) | 19 (5) | 25 (7) | 28 (6) | 0.47 |
| Cannabis (current or lifetime*) | 23 (6) | 21 (6) | 19 (4) | 0.52 |
| Substance use (current or lifetime*) | 232 (76) | 208 (72) | 251 (71) | 0.41 |
| Anticholinergic medication | 127 (21) | 125 (27) | 170 (29) | 0.002 |
| Hypertension | 123 (21) | 71 (16) | 140 (25) | 0.002 |
| Hyperlipidemia | 82 (14) | 44 (10) | 93 (16) | 0.008 |
| Diabetes | 38 (6) | 14 (3) | 30 (5) | 0.05 |
| HCV | 111 (19) | 81 (18) | 125 (22) | 0.18 |
| Log plasma viral load, M (SD) | 3.2 (1) | 3.0 (1.3) | 3.1 (1.4) | 0.05 |
| CD4 count, M (SD) | ||||
| Current | 434.6 (283.1) | 449.9 (305.6) | 406 (303.5) | 0.05 |
| Nadir | 245.1 (214.7) | 259.8 (251.2) | 197.5 (198.3) | <0.001 |
| Duration of HIV disease, M (SD) | 8.9 (7.8) | 7.9 (7.2) | 10.2 (8.2) | <0.001 |
| AIDS diagnosis | 331 (54) | 253 (55) | 385 (66) | <0.001 |
| On ART | 322 (54) | 275 (61) | 369 (65) | <0.001 |
ART, antiretroviral therapy; WRAT-4, Wide Range Achievement Test-4th edition; IADL, Instrumental Activities of Daily Living; BDI, Beck depression inventory; CIDI, Composite International Diagnostic Interview; HCV, Hepatitis C;
*
Current or Lifetime Use disorder (abuse or dependence).