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. 2020 Nov 23;11:594928. doi: 10.3389/fmicb.2020.594928

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Copyright © 2020 Raghav, Ghosh, Turuk, Kumar, Jha, Madhulika, Priyadarshini, Biswas, Shyamli, Singh, Singh, Singh, Datey, Avula, Smita, Sabat, Bhattacharya, Kshatri, Vasudevan, Suryawanshi, Dash, Senapati, Beuria, Swain, Chattopadhyay, Syed, Dixit, Prasad, Odisha COVID-19 Study Group, ILS COVID-19 Team, Pati, and Parida.

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D614G in Spike gene increases infectivity portrayed by Ct values as a surrogate for viral load. (A) Cumulative count of the occurrence of D and G in 614 position of Spike protein in sequenced genomes (n = 202). (B,C) Ct value distribution of S gene and ORF1ab for the sequenced genomes (n = 202). (D–F) Ct value distribution of S gene and ORF1ab in all the positive samples tested at Institute of Life Sciences until June 17, 2020. (G–I) The superimposed 3D structures G614 mutant and wild-type Spike protein. (G) The mutant site is highlighted with a circle at 614 position. (H) The hydrogen bond (D614-T859) shown as dotted line between Spike S1 and S2 domain in wild type. (I) The hydrogen bond is lost as a result of D614G mutation.