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. 2020 Nov 26;11:581313. doi: 10.3389/fmicb.2020.581313

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Copyright © 2020 Venice, Desirò, Silva, Salvioli and Bonfante.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic region containing the putative biosynthetic cluster in the CaGg endobacterium. The cluster contains a NRPS-PKS gene and a neighboring NRPS (29522648 and 29522647, respectively). Protein IDs were retrieved from the MicroScope MaGe platform (https://mage.genoscope.cns.fr/microscope/ home/index.php). A similarity was found with the MIBiG reference clusters for the biosynthesis of althiomycin of Serratia marcescens and Myxococcus xanthus (BGC0000955.1 and BGC0001415.1, respectively). The core biosynthetic genes are linked with dashed lines. Sequence alignment, as well as the distance tree and the PFAM domains prediction, were obtained with BIG-SCAPE.