Table 2. Summary of randomized control trials comparing DEB-TACE to cTACE in the treatment of HCC.
Study | Patient cohort | No. of BCLC B | Results |
---|---|---|---|
Lammer et al 48 | 201 patients, 93 DEB-TACE and 108 cTACE | 69 | OR rate: 51.6 vs. 43.5% for DEB-TACE vs. cTACE ( p = 0.11) |
Golfieri et al 49 | 177 patients, 89 DEB-TACE and 88 cTACE | 26 | Median TTP of 9 mo in both groups. 1- and 2-y survival rates equivalent between DEB-TACE and cTACE (86.2 and 56.8% vs. 83.5 and 55.4%, p = 0.949) |
Sacco et al 83 | 67 patients, 33 DEB-TACE and 34 cTACE | 11 | 24-mo overall survival equivalent between DEB-TACE and cTACE (86.8 vs. 83.6%, p = 0.96) |
van Malenstein et al 84 | 30 patients, 16 DEB-TACE and 14 cTACE | 19 | Rates of stable disease not significantly different between treatment DEB-TACE and cTACE (77 vs. 92%, p = 0.54) |
Abbreviations: BCLC, Barcelona Clinic Liver Cancer; cTACE, conventional transarterial chemoembolization; DEB-TACE, drug-eluting bead TACE; HCC, hepatocellular carcinoma; TTP, time to tumor progression.
Note: The number of BCLC stage B patients included in each randomized controlled trial is noted.