TABLE 1.

Genes and pathways involved in the circadian rhythm regulation of autophagy.

Gene/Pathway	Target molecular	Function	Regulation	Organism/cell culture	References
C/EBPβ	ULK1, LC3B, BNIP3 and GAPRAPL1	Autophagy	Up	Mice	Ma and Lin, 2012
AMPK	ULK1, TSC1/TSC2 and mTOR complex 1	Autophagy	Up	HeLa cells	Shang et al., 2011
PGC-1α/PGC-1β	ULK1, BNIP3, FIP200, GAPRAPL1, ATG2A, ATG16L1 and ATP6V0A2	Autophagy	Up	Mice	Li and Lin, 2015
TFEB/TFE3	Rev-erbα	Autophagy	Up	Mouse	Pastore et al., 2019
FoxO3	LC3B, BNIP3, BNIP3L and GAPRAPL1	Autophagy	Up	Mice	Mammucari et al., 2007; Ruan et al., 2020
SREBF2	PNPLA8	Autophagy	Up	Mice	Oishi et al., 2015; Kim et al., 2016
HSF-1	ATG10 and ATG18	Autophagy	Up	Tomato	Wang et al., 2015; Li et al., 2016
HSF-1	LGG-1/ATG8, LGG-2/ATG8 and EPG-9	Autophagy	Down	C. elegans	Barna et al., 2018
ACBP3	ATG8	Autophagy	Down	C. elegans	Xiao and Chye, 2010