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. 2020 Nov 24;10:592757. doi: 10.3389/fonc.2020.592757

Figure 4.

Figure 4

SNHG7 sponged miR-34a in chemoresistant breast cancer cells. (A) Bioinformatics analysis predicted that SNHG7 harbored miR-34a binding sites. (B) miR-34a expression was associated with pCR of breast cancer after NAC. (C) miR-34a was negatively correlated with SNHG7 expression in breast cancer tissues. (D) Compared with the parental cells, the expression of SNHG7 in MCF-7/ADR and MDA-MB-231/PTX cells was increased, while the expression of miR-34a was decreased. (E) A luciferase activity assay was performed after co-transfection of HEK-293T cells with a reporter plasmid and miR-34a. (F) miR-34a expression increased after transfection with si-SNHG7 into MCF-7/ADR and MDA-MB-231/PTX cells. (G, H) After MCF-7/ADR cells were transfected with the pcDNA3.1-SNHG7plasmid, the expression of SNHG7 increased, whereas it markedly reduced miR-34a expression. *P < 0.05, **P < 0.01 represent a statistically significant difference.