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. 2020 Nov 24;10:590931. doi: 10.3389/fonc.2020.590931

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Copyright © 2020 Yang, Xia, Li, Chen, Zhao, Sun, Ma, Wu, Wang, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shape of rat C6 glioma was revealed by whole-brain slice H&E staining, and 60-day survival curve was analyzed. (A, B) The shape of the glioma (a, gold circle) and tumor core (b, light blue circle) is shown using H&E staining of a tumor tissue coronal slice. Glioma cells and vascular arrangement (arrowhead) observed using optical microscopy (magnification, ×40). (C) On day 18 after establishing the C6 glioma model, the gliomas were removed from the rats and the weight of the fresh tumors was measured. Data are presented as the mean ± standard deviation (n=6/group). (D) The 60-day survival rate was investigated every day after propofol treatment (n=10/group). ^**P < 0.01. Groups: G, glioma; P1 and P2, propofol 20, and 40 mg/kg^-1/h^-1, respectively. H&E, hematoxylin and eosin.