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. 2020 Nov 24;10:590931. doi: 10.3389/fonc.2020.590931

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Copyright © 2020 Yang, Xia, Li, Chen, Zhao, Sun, Ma, Wu, Wang, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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It was revealed that propofol suppressed proliferation and cell cycle progression of glioma cells. (A–C) Cell cycle analysis of C6 glioma cells transduced with propofol or (R, S)-AMPA and analyzed by flow cytometry. (D) For the cell proliferation assay, 6 wells of cells from each group were randomly selected, digested and counted every 24 h for 6 days. Data are presented as the mean ± SD (n=6/group). ^*P < 0.05 and ^**P < 0.01. Groups: S, sham; G, glioma; P1 and P2, propofol 1.2, and 4.4 µg/ml^-1, respectively; A, (R, S)- AMPA.