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. 2020 Nov 27;11:584090. doi: 10.3389/fphar.2020.584090

TABLE 5.

The differential metabolites in serum after DCH treatment.

No Rt (min) m/z Formula Metabolites VIP FC Trend Pathway
M vs. C D vs. M M vs. C D vs. M M vs. C D vs. M
1 1.06 116.0703 C5H9NO2 L-Proline 2.43 0.93 1.86 0.81 ↑## ↓ —
2 0.92 120.0651 C4H9NO3 L-Threonine 2.18 3.55 0.33 3.01 ↓## ↑** b
3 0.76 147.1121 C6H14N2O2 L-Lysine 1.38 0.69 3.24 0.92 ↑## ↓ —
4 2.69 132.1014 C6H13NO2 L-Isoleucine 2.94 1.49 1.98 0.67 ↑## ↓* —
5 1.43 118.0860 C5H11NO2 L-Valine 2.79 2.48 2.38 0.52 ↑## ↓** —
6 0.71 281.2460 C18H32O2 Linoleic acid 1.28 1.13 0.63 1.63 ↓# ↑** a
7 0.88 175.1181 C6H14N4O2 L-Arginine 2.77 1.31 1.94 0.66 ↑## ↓** —
8 2.92 132.1014 C6H13NO2 L-Leucine 3.89 2.08 1.85 0.63 ↑## ↓** —
9 10.42 301.2171 C20H30O2 Eicosapentaenoic acid 1.06 2.73 0.60 1.00 ↓# — —
10 8.80 464.3011 C26H43NO6 Glycocholic acid 1.73 0.43 2.24 0.66 ↑## ↓ —
11 2.30 169.0349 C5H4N4O3 Uric acid 2.37 1.16 1.81 0.65 ↑## ↓** —
12 0.95 114.0659 C4H7N3O Creatinine 2.01 0.77 3.29 0.75 ↑## ↓ —
13 14.29 283.2639 C18H36O2 Stearic acid 2.30 1.88 2.04 0.53 ↑## ↓** —
14 9.52 391.2857 C24H40O4 Ursodeoxycholic acid 1.66 0.64 2.25 0.75 ↑## ↓ —
15 9.83 241.0560 C6H12O7 Gluconic acid 1.23 0.89 0.63 0.99 ↓## ↓ —
16 10.85 730.2405 C26H45NO21 Lacto-N-tetraose 1.12 1.31 0.87 0.92 ↓# ↓ —
17 0.83 940.8140 C56H112NO8P Phosphatidylcholine 2.30 2.02 0.49 1.93 ↓## ↑** c, e
18 10.99 279.2327 C18H32O2 Rumenic acid 5.93 3.92 0.50 1.86 ↓## ↑** —
19 10.58 766.4845 C45H70NO8P Phosphatidylethanolamine 1.33 2.88 1.31 0.79 ↑# ↓* c
20 5.77 203.0816 C11H12N2O2 L-Tryptophan 1.52 0.67 1.88 0.85 ↑## ↓ d
21 9.43 319.2273 C20H32O3 12(R)-HETE 4.68 2.49 1.83 0.46 ↑## ↓** e
22 9.54 317.2116 C20H32O4 5-HPETE 1.20 2.13 1.54 0.50 ↑# ↓** e
23 0.83 151.0721 C2H5NO2 Glycine 1.12 2.02 1.56 0.47 ↑# ↓** b
24 5.75 188.0697 C11H9NO2 Indoleacrylic acid 0.86 3.33 1.22 0.47 ↑ ↓* —
25 1.72 150.0576 C5H8O2S THTC 0.64 1.32 1.39 0.44 ↑ ↓* —

Control, model, positive control and DCH (n = 10 per group) groups. #, p < 0.05 as compared to the control group; ##, p < 0.01 as compared to the control group; *, p < 0.05 as compared to the model group; **, p < 0.01 as compared to the model group; ↑, content increased; ↓, content decreased; vs., versus; C, control group; M, model group; D, DCH group. (a) Linoleic acid metabolism. (b) Glycine, serine and threonine metabolism. (c) Glycerophospholipid metabolism. (d) Tryptophan metabolism. (e) AA metabolism.