Table 2.

List of significantly deregulated miRNAs in skeletal muscles of cachectic individuals suffering from tumors.

Organism (Study)	Tumor type	miRNAs	Alteration type	Known miRNA functions in the skeletal muscle
Human (Narasimhan et al. (150))	Pancreatic and colon cancer	let-7d-3p, miR-199a-3p, miR-345-5p, miR-423-5p, miR-423-3p, and miR-532-5p, miR-1296-5p, miR-3184-3p	Upregulated	None
Human (Van de Worp et al. (151))	Non-small cell lung cancer	miR-335-3p, miR-424-5p, miR-424-3p, miR-450a-5p, miR-450b-5p	Upregulated	None
		miR-15b-5p, miR-20a-3p, miR-26a-2-3p, miR-103-3p, miR-144-5p, miR-370-3p, miR-379-5p, mir-409-3p, miR-451a, miR-483-5p, miR-483-3p, miR-485-3p, miR-512-3p, miR-517a-3p, miR-517c-3p, miR-518b, miR-519a-3p, miR-520g-3p, miR-520h, miR-522-3p, miR-656-3p, miR-766-3p, miR-1255b	Downregulated	miR-15b-5p negatively modulates myogenesis and cell proliferation; promotes muscle stem cell quiescence; modulates mitochondrial-dependent apoptosis; downregulates the insulin-PI3K-AKT signaling. miR-451a inhibits myogenic differentiation; regulates lipid metabolism; regulates energetic state and mitochondrial activity.
Mouse (Soraes et al. (152))	C26 colon carcinoma	miR-133a-3p, miR-140, miR-489, miR-519e, miR-7029	Upregulated	miR-133a-3p modulates myogenesis; regulates cytoskeletal organization.
		Let-7f-5p, let-7g-5p, let-7i-5p, miR-1-3p, miR-15a-5p, miR-15b-5p, miR-23a-3p, miR-23b-3p, miR-24-3p, miR-26b-5p, miR-27a-3p, miR-27b-3p, miR-143-3p, miR-195a-5p, miR-199a-3p, miR-422b-3p, miR-497a-5p	Downregulated	miR-1-3p promotes myogenesis and prevents proliferation; regulates cytoskeletal organization and chromatin structure. miR-15a/b-5p negatively modulate myogenesis and cell proliferation; promote muscle stem cell quiescence; modulate mitochondrial-dependent apoptosis; downregulate the insulin-PI3K-Akt signaling. miRNAs of the miR-23a/b clusters prevent muscle atrophy; promote muscle hypertrophy; modulate myogenic gene expression; modulate mitochondrial acticity. miR-143-3p downregulates glycolysis.
Mouse (Lee et al. (153))	Lewis lung cancer	miR-147-3p, miR-205-5p, miR-223-3p, miR-511-3p	Upregulated	None
		miR-229a-3p, miR-431-5p, miR-665-3p, miR-1933-3p, miR-3473d	Downregulated	None
Mouse (Fernandez et al. (154))	Lewis lung cancer	miR-144-5p, miR-144-3p, miR-181c-3p; miR-379-3p, miR-451a	Upregulated	miR-144-3p reduces glucose uptake and glycolysis; modulates the insulin-PI3K-Akt signaling; indirectly influences the mitochondrial activity. miR-181c-3p promotes myoblast differentiation. miR-451a inhibits myogenic differentiation; regulates lipid metabolism; regulates energetic state and mitochondrial activity.
		miR-10b-5p, miR-29b-3p, miR-146a-5p, miR-146b-5p, miR-183-5p, miR-223-3p, miR-338-5p, miR-350-3p, miR-382-5p, miR-671-3p, 1249-3p, miR-1843a-3p, miR-3535	Downregulated	miR-29b-3p promotes myoblast differentiation and prevents cell cycle progression.