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. 2020 Nov 24;10:584733. doi: 10.3389/fonc.2020.584733

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Copyright © 2020 Chen, Liu, Yi, Qiu and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The identification of DNA methylation-driven genes in GC. (A) The work-flow in this study. (B) The Venn diagram of the DEgenes, Surgenes and Methygenes in 415 GC patients, of which 39 DNA methylation-driven genes are identified to be associated with overall survival of patients with GC. DEgenes, differentially expressed genes; Surgenes, survival-associated genes; Methygenes, methylation-associated genes. (C) 1000 iterations of Cox LASSO regression with 10-fold cross-validation is conducted to reduce the number of DNA methylation-driven genes. (D) A total of 5 DNA methylation-driven genes with nonzero coefficients are selected as candidate predictors.