Table 1. The association of any VTE or recurrent VTE with genotypes for F5, FAM134B, MYH8, and two MYH variant sets containing either 7 or 9 MYH SNPs.
The association of F5 rs6025, FAM134B rs78314670, MYH8 rs111567318, and two variant sets of MYH variants were made for all VTE cases (N=104) vs controls (N=211) and for adult recurrent VTE cases (N=32) vs. controls (N=211), as noted. See Table 4S listing for 7 rare MYH variants with MAF < 0.01 and 2 uncommon MYH variants with MAF > 0.01 and < 0.05 which were used to define sets of MYH variants that were collapsed into the two variant sets used for comparisons in this Table.
| Gene | SNP | MAF | p value | |||
|---|---|---|---|---|---|---|
| control (N=211) | VTE all cases (N=104) | VTE recurrence (N=32) | VTE all cases | VTE recurrence | ||
| F5 | rs6025 | 0.021 | 0.130 | 0.141 | 3.46 x 10−8 | 2.68 x 10−6 |
| FAM134B | rs78314670 | 0.002 | 0.037 | 0.078 | 3.10 x 10−4 | 3.37 x 10−7 |
| MYH8 | rs111567318 | 0 | 0.019 | 0.047 | 4.10 x 10−3 | 8.55 x 10−6 |
| MYH variant set | 7 rare SNPs (MYH1,2,8) | 0 | 0.063 | 0.156 | 2.11 x 10−7 | 2.70 x 10−16 |
| MYH variant set | 7 rare + 2 uncommon SNPs (MYH1,2,4,8) | 0.047 | 0.125 | 0.219 | 4.30 x 10−4 | 6.03 x 10−7 |