FIGURE 2.

Comparison of SpaP and BspA Protein Structures. (A) PyMOL was used to combine the published models for domains of SpaP (N-terminus PDB:4TSH, A3VP1 PDB:3IOX, C-terminus PDB:6E3F) and BspA (V-domain, C-terminus PDB:5DZA). Additional SpaP A and P repeats were modeled from A3VP1, as were the A- and P-domains for BspA. As there is no structure for the N-terminal domain of any AgI/II protein among the cluster of invasive species shown in Figure 1A, the BspA N-terminus is depicted by an oval. Light blue indicates the N-terminal domain, purple indicates the A-domain, green indicates the V-domain, yellow indicates the P-domain, and the shades of orange indicate different globular domains at the C-terminus. The V-domain of SpaP (B) and BspA (C) have been enlarged with arrows pointing to binding pockets.