FIGURE 3.

(A) Comparison of the three κ light chain antibodies, which also show a big spread in the elbow angle in the crystal structures. The specific anti-progesterone antibody DB3 (PDB: 1DBA) is colored in green. The 8F5 antibody (PDB: 1BBD) is colored in red, and the X-ray structure of the murine antibody which has a high specificity toward α-(2→8)-linked sialic acid polymers (PDB: 1PLG) is colored light blue. Additionally, the FFT of the respective distributions are displayed, showing the angle variations occurring faster than 1 ns, between 0.1 and 10 ns, and slower than 10 ns. (B) Histograms of the respective interface and elbow angle distributions, including the respective X-ray structures of all three κ light chain antibodies, which were used as starting structures for molecular dynamics simulations.