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. 2020 Dec 12;12(9):717–733. doi: 10.1007/s13238-020-00811-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transmission electron microscopy analysis of SARS-CoV-2 infected human airway and alveolar organoids. (A–D) Infected hAWOs were fixed and observed under TEM at 96 h post infection. A part of the organoids in one mesh was overviewed (A) and the virus particles in an infected cell were shown (B–D). (E–G) Infected hALOs were fixed at 72 h post infection. A part of the organoids in one mesh (E) and the virus particles in an infected cell (F and G) were shown. (H–R) Representative virus particles and typical structures induced by virus infection in hAWOs (H–N) and hALOs (O–R). Virus particles outside cells at the apical (H), basolateral (I) and lateral side (J). Typical coronavirus replication organelle including double membrane vesicles (DMVs, indicated by asterisks) and convoluted membranes (CMs) with spherules (K). Membrane-bound vesicles with one or groups of virus particles (L). Enveloped virus particles in Golgi apparatus (M). Enveloped virus particles in secretory vesicles (N). Virus particles in a lamella body (O). Virus particles in a late endosome with engulfed cell debris (P and Q). Virus particles in disintegrated dead cells (R)