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. 2020 Oct 20;119(10):1946–1957. doi: 10.1016/j.bpj.2020.08.044

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© 2020 Biophysical Society.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Changes in RI distribution of HeLa-FUCCI cells under chromatin condensation. (a–c) Shown is the maximal projection of RI tomograms of HeLa-FUCCI cells in (a) control, (b) TSA, and (c) ANA treatment. Scale bars, 20 μm. (d) Given are the mean RI-values of cytoplasm, perinuclear cytoplasm, nucleoplasm, and nucleoli in individual cells under chromatin condensation. The dashed line indicates the mean RI-value of cytoplasm in control cells. (e) Given are the relative changes of the mass, volume, and sphericity of the cytoplasm and nuclei under TSA and ANA treatment compared with control. (f) Shown is the mass density ratio between nucleoplasm/cytoplasm (ρ_np/ρ_c), nucleoplasm/perinuclear cytoplasm (ρ_np/ρ_pc), and nucleoli/nucleoplasm (ρ_nl/ρ_np) at the same phases of the cell cycle. The dashed lines indicate equal mass density of the compartments. The numbers of cells measured are N = 1565, 437, and 924 for control, TSA, and ANA treatments, respectively. (g) Given is a schematic indicating the effect of the TSA and ANA treatment on the volume, RI, and shape of cells. To see this figure in color, go online.