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. 2020 Nov 30;15:9517–9537. doi: 10.2147/IJN.S277352

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© 2020 Elsenosy et al.

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Mean brain homogenate concentration-time profiles of IN DLX in situ cubo-gel in comparison to IN solution, IV formula, and IV solution after the administration in Swiss albino rats. The in situ cubo-gel showed higher AUC_0-inf compared to the IN solution with relative bioavailability of 196.13%.

Abbreviations: DLX, duloxetine; IN, intranasal; IV, intravenous; AUC_0-inf., area under the curves from zero to infinity.