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. 2020 Oct 20;119(10):2019–2028. doi: 10.1016/j.bpj.2020.10.010

Figure 9.

Figure 9

Cluster analysis of MD trajectory showing how the conformation of the L17 region defines the overall structure of the PRD. (A) Shown is a schematic of the PRD connected to the polyQ fibril core of HTTex1 fibrils. (B) Centroids of the K-means cluster analysis are shown. The percentages of total frames they represent are indicated. Clusters 2 and 3 are relatively extended, whereas cluster 1, having a strong kink in the L17 region, is less extended. To see this figure in color, go online.