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. 2020 Dec 11;11(12):1049. doi: 10.1038/s41419-020-03244-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A The UALCAN database showed that PDK1 was over-expressed in cervical cancer (tumor) compared with normal cervix (normal). B Analysis of GEO database (GSE7803) showed the NCAPH expression in normal cervix (NC), high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cell cancer (SCC). C The cBioportal database revealed the co-expression of NCAPH and PDK1 in cervical cancer. D–F Western blot analysis showed the changes in the levels of key molecules of PI3K/AKT/SGK pathway after the knockdown of NCAPH expression in HeLa and SiHa cells. The relative protein level was analyzed. G–I Western blot analysis showed the protein levels of NCAPH, p-AKT(Ser473) and total AKT in RPE1-pBabe or RPE1-16E7 cells with or without transfection. The relative protein level was analyzed. NC, negative control siRNA; siNCAPH, siRNA targeting NCAPH gene. Data are presented as mean ± SD (n = 3). * represents p < 0.05, ** represents p < 0.01, *** represents p < 0.001, ns not significant.