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. 2020 Dec 11;10:21778. doi: 10.1038/s41598-020-78688-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kinetics of liver inflammation in the NIF mice. (A) Body weights, (B) liver weights and (C) liver-to-body weight ratios of the NIF mice (filled circle, shaded bars) (n = 8–11) and 2,4αβNOD.Rag2^+/− control mice (open circle, open bars) (n = 5–10). *P < 0.05, **P < 0.01 and ***P < 0.001, Mann–Whitney U test after Bonferroni correction. Representative H&E-stained liver sections from (D) 4-week-old (E) 6-week-old (F) 8-week-old and (G) 18-week-old NIF mice. Framed areas are highlighted. Scale bars are 200 μm in the overview images and 50 μm in the highlighted images. Semiquantitative assessment of (H) periportal infiltrates, (I) sinusoidal infiltrates and (J) bile duct hyperplasia in the NIF mice (n = 8–11) (n = 5–10) at the indicated ages.