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. 2020 Dec 11;6:40. doi: 10.1038/s41531-020-00143-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Metabolic profiling of whole Drosophila brains in Seahorse XFe96-well culture microplates (Agilent) reveals decreased oxygen consumption rate (a, OCR), basal respiration, maximal respiration, and proton leak (b). c Neuronal knockdown of Gch1 further suppresses the basal oxygen consumption rate reduction in α-synuclein transgenic flies when compared to flies expressing α-synuclein alone. d The energy map reveals that neuronal knockdown of Gch1 enhances the whole brain energy deficit induced by α-synuclein expression. e Dietary folate supplementation partially normalizes the basal oxygen consumption rate reduction in α-synuclein transgenic flies when compared to flies expressing α-synuclein not receiving folate. f The energy map shows that folate supplementation partially rescues the whole brain energy deficit induced by α-synuclein expression. Control genotype: nSyb-QF2, nSyb-GAL4/+. All data are represented as mean ± SEM. Data are analyzed using one-way ANOVA with Tukey post-hoc test for multiple groups. *p < 0.05, **p < 0.01, ***p < 0.005, n = 3–6. Flies are 10 days old.