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. 2020 Dec 11;6:40. doi: 10.1038/s41531-020-00143-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Cell type distribution of proteins that are differentially expressed when human α-synuclein is expressed in fly neurons. Each bar shows the number of upregulated (red), downregulated (dark blue), and total measured (white) proteins within cell type subgroups. The clusters are separated into three groups: glial (highlighted in light blue on the x-axis), neuronal (highlighted in green on the x-axis), and unannotated (highlighted in gray on the x-axis)⁴². Glial knockdown of Gch1 does not modify α-synuclein induced (b) climbing deficits, (c) locomotor activity deficits, or (d) basal oxygen consumption rate reduction when compared to flies expressing α-synuclein alone. Control genotype: nSyb-QF2, nSyb-GAL4/+. All data are represented as mean ± SEM. Data are analyzed using one-way ANOVA with Tukey post-hoc test for multiple groups. n = 3–6. Flies are 10 days old.