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. 2020 Dec 11;11:6344. doi: 10.1038/s41467-020-20200-5

Fig. 9. BLP modulates immune cell populations to maintain intestinal immune homeostasis.

Fig. 9

a–h Representative immunohistochemical micrographs of ileal tissues showing increased CD4+ cells (a, brown, arrows), FOXP3+ T-regulatory cells (c, brown, arrows), CD11c+ dendritic cells (f, brown, arrows), and NKp46+ cells (h, brown, arrows) in BLP-treated mice (10 days) mice pre- or post Lm challenge at 48 hpi, relative to naive or LbcWT-treated (10 days). Bars, 10 µm. Quantification of CD4+ cells (b), FOXP3+ T-regulatory cells (d), CD11c+ dendritic cells (e), and NKp46+ cells (g). Each point (b, d, e, and g) represents an average (mean ± SEM) of 25 villi from a single mouse, four mice per group, n = 100 villi. Statistical significance (b, d, e, and g) was determined by using the one-way ANOVA followed by a Tukey’s multiple comparisons. For all analysis, ***P < 0.001; **P < 0.01; *P < 0.05; ns no significance. Source data are provided as a Source Data file.