Table 3. Proteins interacting with Keap1, verified by biochemical methods.

The location of interacting amino acids was shown for human (h) proteins. Presence of the interacting motif was also verified in mouse (m) and rat (r) proteins based on the sequence search. X - unspecified amino acid.

Protein name and symbol	Function	Motif interacting with Keap1	Reference
Actin	Cytoskeleton	n.d.	[128]
BPTF/FAC1	Chromatin regulation	n.d.	[129]
Cdk20	Cell cycle	25ETGE28, h m r	[130]
DPP3	Protein degradation	480ETGE483, h m r	[113,116,131]
EGFR	Growth factor signalling	n.d.	[96]
Fam129b	Apoptosis suppression, signalling	708DLG710, h 718ETGE721,h m r	[132]
Gankyrin	Proteasome subunit	21ELKE24, h m r 201ENKE204, h m r	[133]
GAPDH	Metabolism	n.d.	[75]
HBXIP	Amino-acid sensing, viral response	110GLNLG115, h	[134]
HSP90	Protein folding	n.d.	[135]
IKKB	Regulation of NFkB signaling	36ETGE39, h	[76,77]
KPNA6 (importin α7)	Nuclear import of Keap1	ARM domain	[136]
MAD2A	Cell division	92ESGE96, h m	[137]
MCM3	DNA replication	387ESGE390, h m r	[80,138]
Nestin	Intermediate filament	1414ESGE1417, h m r DLG – predicted	[127]
NOS3	Production of nitric oxide	n.d.	[75]
p65	Inflammation	n.d.	[139]
PALB2	DNA repair	91ETGE94, h m r	[140,141]
PGAM5	Necrosis	79ESGE82, h m r	[78,79,142,143]
PIDD	Apoptosis	n.d.	[126]
PTMA	Chromatin remodeling	43ENGE46, h m r	[13,144,145]
RelA-associated inhibitor (iASPP)	p53 regulator	239DLT241, h	[146]
RMP	Gene transcription regulation	EXXE, h m	[147]
p62	Autophagy	349STGE352,h m r (phosphorylated)	[148,149]
WTX, AMER1	Regulation of Wnt signaling pathway	288ETGE291, h	[73,150]