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. 2020 Dec 10;27:9–16. doi: 10.1016/j.jot.2020.10.011

Figure 5.

Figure 5

SU11274 ameliorated pathological bone loss in CIA mice. (a) Time course changes in arthritis clinical score from CIA mice treated with PBS, and SU11274 respectively (n ​= ​6). (b) Representative TRAP staining images and parameters of distal femoral osteoclasts from CIA mice (n ​= ​12). Scale bars were 100 ​μm and 25 μm. (c) Representative micro-CT images (trabecular bones, Scale bars, 0.5 ​mm; cortical bones, Scale bars, 1 ​mm) from the hind paws of mice (n ​= ​6). (d) The values of micro-CT parameters (BMD, BV/TV, BS/TV, Tb.Th, Tb.N and Tb. Sp) of the proximal tibial bones from the CIA mice after treatment in the respective group (n ​= ​6). All data are shown as means ​± ​SD; ∗p ​< ​0.05, ∗∗p ​< ​0.01.