Fig. 3.

Estradiol add-back treatment reversed the impairment in endothelial function with ovarian suppression alone in premenopausal women and increased endothelial function in perimenopausal and postmenopausal women to normal premenopausal levels. Brachial artery FMD before and following GnRH antagonist (GnRH_ant) alone and with placebo or estradiol add-back treatment. Data are means ± SE. ^*p < 0.01 vs. baseline of the same group; ^†p < 0.05 vs. GnRH antagonist alone condition of the same group; ^‡p < 0.01 vs. baseline condition of the same group; ^‖p < 0.001 vs. placebo add-back condition of the same group