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. 2020 May 26;42(6):1579–1591. doi: 10.1007/s11357-020-00200-5

Fig. 3.

Fig. 3

A loss of Sod1 induces muscle atrophy through ubiquitin protein systems. a A representative Western blot of total ubiquitin-bound protein bound and free ubiquitin from cytosolic fraction from 11 to 16-month-old muscle. b 20S Chymotrypsin-like proteasome activity from 5 month (top) and 20 month (bottom) old muscle. Values were compared using student t test; *p < 0.05. c A quantification of native gel analyses of different proteasome assembly muscle homogenates at 15 months of age. Values were compared using student t test; *p < 0.05. Protein levels of 20S proteasome subunit α7 (d) and β5 (e), 19S subunit Rpt5 (F), and 11S proteasome activator PA28α (g). Values were compared using student t test; *p < 0.05, **p < 0.01, and ***p < 0.001