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. 2020 Dec 10;23(1):118–128. doi: 10.1016/j.neo.2020.11.012

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Changes in gene expression of SCC-25 cancer cells with the effect of MSC. (A) Pattern of gene expression of sorted SCC-25 and fused MSC/SCC cells were compared to naïve SCC-25. Heatmap showing gene-level counts with lower than median (green), greater than median (red) and median (black) levels of expression. (B) Each row represents a single gene. (C) Network modeling of the interacting genes implicated mostly in drug resistance. (D) PCR of CD36, GDF15, CXCL11, TFPI-2, DAPK,1 POSTN, and IGFBP5 to validate genes obtained in the RNA-seq heatmap. MSC, Mesenchymal stem cells; SCC, squamous cell carcinoma. (Color version of figure is available online.)