Figure 9.

In vivo experiments

(A) H&E staining of plaques following treatment with miR-145-rich exosomes. The chart shows lumen/artery ratio. After miR-145-rich exosome treatment, the lumen area increased, suggesting that the stenosis level decreased. ∗∗p = 0.0098. (B) Immunohistochemistry was used to evaluate JAM-A expression in plaques. (C) Western blot showed that JAM-A expression was inhibited after miR-145-rich exosomes treatment, the relative JAM-A expression is shown in the following chart. After miR-145-rich exosomes treatment, JAM-A expression decreased. ∗∗p = 0.0057.