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. 2020 Dec 7;12:12527–12534. doi: 10.2147/CMAR.S258230

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© 2020 Guan et al.

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CircRNA_102272 facilitates HCC cisplatin-resistance by regulating the miR-326/RUNX2 axis. (A) The estimated binding sites of miR-326 and RUNX2. (B) Luciferase reporter assay confirmed their complementary combinations. (C) RUNX2 expression was significantly increased in HCC tissues compared to normal tissues. (D) MiR-326 expression inversely correlates with RUNX2. (E) CircRNA_102272 expression positively correlates with RUNX2. (F) RUNX2 expression were detected by RT-PCR. (G) Cell proliferation was assessed by the CCK8 assay. (H) IC₅₀ values of cisplatin were evaluated by the CCK8 assay. (I) CircRNA_102272 facilitated HCC cisplatin-resistance by regulating the miR-326/RUNX2 axis. The data shown represent the mean ± SD. *p < 0.05, ^nsp > 0.05. oeRUNX2: overexpression of RUNX2.