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. 2020 Nov 4;23:142–153. doi: 10.1016/j.omtn.2020.10.042

Figure 1.

Figure 1

Effect of pulmonary endothelial miR-150 supplementation on development of PH in Sugen/hypoxia mice

(A) Experimental layout. (B–D) Right ventricular systolic pressure (RVSP) (B), right ventricular hypertrophy (RVH; right ventricle to left ventricle + septum ratio [RV/LV+S]) (C), and percentage (D) of muscularized vessels <50 μm in diameter/total number of vessels in the lungs of normoxia control mice and Sugen/hypoxia mice treated with scrambled control or miR-150 mimic delivered by intravenous (i.v.) administration of DACC lipoplex, as indicated. (E) Representative images of α-SMA staining in lung sections from Sugen/hypoxia mice treated with scrambled control or miR-150 mimic. (F and G) miR-150 expression in lung and heart, as indicated; fold change of normoxia control. ∗p < 0.05, ∗∗p < 0.005, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, comparisons with normoxia control; #p < 0.05, ###p < 0.001, ####p < 0.0001, comparisons with scrambled control (by one-way ANOVA with a Tukey’s post-test.). Bars are means ± SEM. n = 8 mice/group.