Figure 6.

miR-150 and PTPMT1 modulate cardiolipin levels in tissues and cells

(A–C) Lung PTPMT1 mRNA (A), lung cardiolipin (B), and heart cardiolipin (C) levels in control and DACC/miR-150-treated Sugen/hypoxia mice, as indicated. (D) Cardiolipin levels in control HPAECs and HPAECs transfected with miR-150 and PTPMT1, as indicated. In (A), data are expressed as fold change of normoxia control. Bars are mean of ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, comparison with transfection control (by one-way ANOVA with a Tukey’s post-test). n = 4–8.