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. 2020 Dec 10;8(2):e001315. doi: 10.1136/jitc-2020-001315

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Association between EPHA mutations and survival in patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors in the validation cohort 1. (A) Kaplan-Meier survival curves comparing progression-free survival (PFS) between the EPHA^mut group and EPHA^wt group in validation cohort. (B) The ratio of patients with complete response (CR), partial response (PR), stable disease (SD) and progression disease (PD) treated with anti-PD-(L)1 antibody in EPHA mutation and EPHA wide-type group. (C) Pooled estimates of PFS. The squares in yellow represent study-specific HRs. The squares in orange indicate the pooled HRs. Horizontal lines indicate the 95% CIs. The p values for heterogeneity and the values of I² are from the pooled analysis of study-specific HRs. *P<0.05 by Fisher’s exact test.