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. 2020 Dec 10;8(2):e001315. doi: 10.1136/jitc-2020-001315

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Associations between EPHA status and immune response-related genes and transforming growth factor (TGF)-β signaling-related genes mRNA expression. (A) The enrichment in TGF-β signaling by Gene Set Enrichment Analysis (GSEA) between EPHA mutation and EPHA wild-type groups in lung adenocarcinoma (LUAD). (B) The enrichment in interferon-γ response signaling by GSEA between EPHA mutation and EPHA wild-type groups in LUAD. (C) Box plot comparing the expression of immune-related genes between patients with EPHA mutation and EPHA wild-type in LUAD. (D) Box plot comparing the expression of TGF-β signaling-related genes between patients with EPHA mutation and EPHA wild-type in LUAD. (E) Box plot comparing the expression of immune-related genes between patients with EPHA mutation and EPHA wild-type in lung squamous cell carcinoma (LUSC). (F). Box plot comparing the expression of TGF-β signaling-related genes between patients with EPHA mutation and EPHA wild-type in LUSC ** False discovery rate (FDR)<0.05; ***False discovery rate (FDR)<0.01.