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Antiviral activity and cytotoxicity of ProTide prodrugs of purine analogues
aEffective concentration of compound required to reduce HCV replication by 50% (EC50). bConcentration of inhibitor reducing cell viability by 50% (CC50). cParent nucleoside. dα-Methyl alanine methyl ester used as an amino acid. A, adenine; Bn, benzyl; Et, ethyl; G, guanine; Me, methyl; Ph, phenyl; ProTide, aryloxy phosphoramidate; t-Bu, tert-butyl; 1-Nap, 1-napthyl; 4-CIPh, 4-chlorophenyl.
