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Antiviral activity of cyclic phosphoramidate prodrugs of 2′-C-methylcytosine
aFrom [24] and [50]. bEffective concentration of compound required to reduce HCV replication by 50% (EC50). cIntracellular nucleoside triphosphate (NTP) after incubation at 10 μM with human hepatocytes. dSlow eluting phosphorous diastereomer by reverse phase (RP)-HPLC. eFast eluting phosphorous diastereomer by RP-HPLC.
