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Metabolic activation and antiviral activity of SATE monophosphate prodrugs
aEffective concentration of compound required to reduce HCV replication by 50% (EC50). bConcentration of inhibitor reducing cell viability by 50% (CC50). cParent nucleoside (Nuc). C, cytosine; SATE, S-acyl-2-thioethyl; t-Bu, tert-butyl; U, uracil.
