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. 2020 Dec 11;18:478. doi: 10.1186/s12967-020-02659-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Loss of TGFβrIII protein in breast cancer. TGFβrIII expression was analyzed by immunohistochemistry (IHC) using anti TGFβrIII (sc-74511) and chromogenic detection. IHC staining was scored on a 0 to 3 scale by a board-certified pathologist, 0 corresponding to no staining and 3 to high staining levels. H&E staining of benign breast tissue lesion (a) and breast cancer (d). Representative staining of TGFβrIII in a benign breast lesion (b, 20x; c 40x), with positive epithelial (asterisk) and myoepithelial cells (arrows). Similar results were obtained in healthy breast tissue, obtained as an internal control from each sample (g, 20x). Staining of TGFβrIII in breast cancer tissues (e, 20x; f, 40x) showed no reaction in the majority of analyzed samples. Secondary antibody only control (h); positive tissue control, benign breast tissue lesion (i). Note the significant decrease in staining intensity in breast cancer (e, f) in comparison to healthy tissues (g) and benign lesion of breast tissue (b, c)