Table 2.
Modules analysis of the protein–protein interaction network.
| Category | Module | Score | Nodes | Enrichment and pathway description | Gene |
|---|---|---|---|---|---|
| Upregulated DEGs | a | 20 | 20 | GO: 0007186: G protein-coupled receptor signaling pathway | Ackr3, Anxa1, Bdkrb1, Bdkrb2, C5ar1, Ccr1, Ccr5, Cxcl1, Cxcl2, Cxcl3, Cxcl5, Cxcr2, Fpr1, Gal, Gpr31b, Hcar2, Pf4, S1pr1, S1pr3 |
| GO: 0006954: Inflammatory response | Anxa1, Bdkrb1, Bdkrb2, C5ar1, Ccr1, Ccr5, Cxcl1, Cxcl2, Cxcl3, Cxcl5, Cxcr2, Fpr1, Gal, Pf4, S1pr3 | ||||
| mmu04062: Chemokine signaling pathway | Ccr1, Ccr5, Cxcl1, Cxcl16, Cxcl2, Cxcl3, Cxcl5, Cxcr2, Pf4 | ||||
| mmu04060: Cytokine–cytokine receptor interaction | Ackr3, Ccr1, Ccr5, Cxcl1, Cxcl16, Cxcl2, Cxcl5, Cxcr2, Pf4 | ||||
| b | 9 | 9 | GO: 0002764: Immune response-regulating signaling pathway | Cd14, Fcgr2b, Fcgr3, Ptafr | |
| GO: 0050778: Positive regulation of immune response | Cd14, Cd44, Fcgr2b, Fcgr3, Ptafr | ||||
| mmu04145: Phagosome | Cd14, Fcgr3 | ||||
| c | 7.259 | 28 | GO: 0006954: Inflammatory response | Adam8, Ccl2, Ccl3, Ccl7, Fcer1g, Hmox1, Hp, Icam1, Il10, Il6, Ptgs2, Serpina3n, Slc11a1, Thbs1, Timp1, Tnfrsf1b | |
| GO: 0034097: Response to cytokine | Ccl2, Ccl3, Ccl7, Fcer1g, Icam1, Il6, Ptgs2, Serpina3c, Serpina3f, Serpina3m, Serpina3n, Serpine1, Slc11a1, Timp1, Tnfrsf1b | ||||
| mmu04668: TNF signaling pathway | Ccl2, Icam1, Il6, Ptgs2, Tnfrsf1b | ||||
| mmu04060: Cytokine–cytokine receptor interaction | Ccl2, Ccl3, Ccl7, Il10, Il6, Tnfrsf1b | ||||
| d | 5.143 | 8 | GO: 0006469: Negative regulation of protein kinase activity | Cblb, Il1b, Socs1, Socs3 | |
| GO: 0016567: Protein ubiquitination | Cblb, Socs1, Socs3, Spsb1, Znrf1 | ||||
| mmu04120: Ubiquitin mediated proteolysis | Cblb, Socs1, Socs3 | ||||
| mmu04630: JAK-STAT signaling pathway | Csf3, Socs1, Socs3 | ||||
| Down-regulated DEGs | e | 8 | 9 | GO: 0045087: Innate immune response | Herc6, Ifit1, Ifit3, Irf7, Oasl2, Stat2, Zbp1 |
| GO: 0060340: Positive regulation of type I interferon-mediated signaling pathway | Irf7, Zbp1 | ||||
| GO: 0035457: Cellular response to interferon-alpha | Ifit1, Ifit3 | ||||
| GO: 0035458: Cellular response to interferon-beta | Ifit1, Ifit3, Stat2 | ||||
| mmu04621: NOD-like receptor signaling pathway | Irf7, Stat2 |