Table 4.
Univariate and Multivariate Cox Regression Analysis on Associations between SMALLL Signature and OS of BC Patients in Training Group
| Total | High risk score | Low risk score | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|---|
| Cases, n (MST) | Cases, n (MST) | HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Overall | 188 | 94 (15.7) | 94 (62.9) | 1.9 (1.48–2.43) | <0.001 | 1.8 (1.35–2.39) | <0.001 |
| Age, years | |||||||
| <70 | 98 | 42 (19.4) | 56 (55.4) | 1.01 (0.98–1.05) | 0.52 | 1 (0.95–1.04) | 0.84 |
| ≥70 | 90 | 52 (13.3) | 38 (–) | ||||
| Sex | |||||||
| Female | 45 | 28 (8.8) | 17 (–) | ||||
| Male | 143 | 66 (16.8) | 77 (60.3) | 0.37 (0.17–0.81) | 0.01 | 0.76 (0.29–1.98) | 0.58 |
| Grade | |||||||
| High | 179 | 93 (14.6) | 86 (58.2) | — | — | — | — |
| Disease stage | |||||||
| II | 53 | 16 (55.2) | 2.1 (1.27–3.47) | <0.05 | 0.76 (0.31–1.84) | 0.54 | |
| III | 65 | 37 (13.4) | 28 (47.1) | ||||
| IV | 68 | 40 (11.7) | 28 (26.8) | ||||
| T | |||||||
| T2 | 56 | 30 (12.7) | 26 (–) | 2.05 (1.24–3.39) | <0.05 | 1.66 (0.91–3.02) | 0.10 |
| T3 | 88 | 43 (16.8) | 45 (–) | ||||
| T4 | 36 | 18 (14.6) | 18 (55.4) | ||||
| M | |||||||
| M0 | 88 | 41 (12.6) | 47 (65.4) | 2.53 (0.59–10.85) | 0.20 | 1.11 (0.22–5.73) | 0.90 |
| MX | 96 | 51 (16.4) | 45 (33.2) | ||||
| N | |||||||
| N0 | 108 | 53 (16.4) | 55 (–) | 1.9 (1.27–2.85) | <0.05 | 1.52 (0.74–3.13) | 0.26 |
| N1 | 27 | 13 (16.8) | 14 (–) | ||||
| N2 | 31 | 20 (14.7) | 11 (32.4) | ||||
| NX | 16 | 8 (12.5) | 8 (41) | ||||
| Race | |||||||
| Caucasia | 153 | 78 (11.9) | 75 (–) | 0.67 (0.3–1.46) | 0.31 | 0.44 (0.18–1.03) | 0.06 |
| Others | 35 | 16 (16.4) | 19 (–) | ||||
| Recurrence | |||||||
| No | 112 | 51 (53.9) | 61 (–) | 2.88 (1.35–6.13) | <0.05 | 2.09 (0.88–4.96) | 0.09 |
| Yes | 76 | 43 (14.7) | 33 (30.3) | ||||
Abbreviations: BC, bladder cancer; MST, median survival time; OS, overall survival.–