Table 5.
Univariate and Multivariate Cox Regression Analysis on Associations between SMALLL Signature and OS of BC Patients in Validation Group
| Total | High risk score | Low risk score | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|---|
| Cases, n (MST) | Cases,n (MST) | HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Overall | 184 | 92 (26.4) | 92 (43.4) | 1.07 (0.83–1.38) | 0.04 | 1 (0.72–1.4) | 0.05 |
| Age, years | |||||||
| <70 | 96 | 45 (65.2) | 51 (91.2) | 1.05 (1.01–1.1) | 0.03 | 1.05 (1–1.1) | 0.04 |
| ≥70 | 88 | 47 (19.1) | 41 (22.3) | ||||
| Sex | |||||||
| Female | 50 | 24 (26.9) | 26 (43.4) | 0.74 (0.33–1.66) | 0.47 | 0.62 (0.26–1.45) | 0.27 |
| Male | 134 | 66 (26.4) | 68 (44.1) | ||||
| Grade | |||||||
| High | 175 | 91 (26.1) | 84 (40.3) | 1.57 (0.93–2.67) | 0.09 | 1 (0.2–5.11) | 1 |
| Low | 9 | 1 (–) | 8 (–) | ||||
| Disease stage | |||||||
| II | 53 | 19 (26.4) | 34 (91.2) | ||||
| III | 69 | 39 (34.7) | 30 (95.3) | ||||
| IV | 62 | 28 (23.1) | 34 (22.3) | ||||
| T | |||||||
| T2 | 56 | 20 (–) | 36 (85.2) | 1.38 (0.74–2.57) | 0.31 | 1.42 (0.39–5.13) | 0.59 |
| T3 | 101 | 57 (10.3) | 44 (5.5) | ||||
| T4 | 27 | 15 (19.7) | 12 (19.3) | ||||
| M | |||||||
| M0 | 87 | 36 (25) | 51 (63.2) | 1.89 (0.44–8.08) | 0.39 | 0.93 (0.13–6.78) | 0.95 |
| M1 | 5 | 4 (–) | 1 (–) | ||||
| MX | 92 | 52 (26.2) | 40 (24.5) | ||||
| N | |||||||
| N0 | 108 | 53 (95.3) | 55 (91.2) | 1.38 (0.93–2.05) | 0.11 | 1.24 (0.42–3.67) | 0.70 |
| N1 | 16 | 9 (33.4) | 7 (37.5) | ||||
| N2 | 44 | 24 (21.4) | 20 (19.9) | ||||
| NX | 16 | 6 (8.5) | 10 (21.9) | ||||
| Race | |||||||
| Caucasian | 145 | 66 (26.9) | 79 (43.5) | 1.47 (0.55–3.94) | 0.44 | 1.15 (0.34–3.91) | 0.82 |
| Others | 39 | 13 (25.7) | 26 (63.6) | ||||
| Recurrence | |||||||
| No | 113 | 51 (44.1) | 62 (95.3) | 1.49 (0.68–3.23) | 0.32 | 1.2 (0.43–3.35) | 0.73 |
| Yes | 71 | 41 (19.8) | 30 (37.5) | ||||
Abbreviations: BC, bladder cancer; MST, median survival time; OS, overall survival.