Table 2.
Overview of Exosomal miRNAs and Functions in Female Reproductive System Cancer and Breast Cancers
| Cancer | miRNA | Recipient Cell | Pathway | Function | Reference |
|---|---|---|---|---|---|
| Breast CA | miR-1910-3p | Breast CA cells | NF-κB and wnt/β-catenin | ↑Tumor cell growth | [39] |
| Breast CA | miR-181D-5p | Breast CA cells | CDX2 and HOXA5 | ↑EMT | [40] |
| Breast CA | miR-4516 | Breast CA cells | FOSL1-dependent TNBC | ↑proliferation and malignancy | [41] |
| Breast CA | miR-3613-3p | Breast CA cells | Targeting the expression of SOCS2 | ↓proliferation and metastasis | [42] |
| Breast CA | miR-27a-3p | γδT1 cells | Up-regulating PD-L1 through the MAGI2/PTEN/PI3K | ↑immune escape | [86] |
| Breast CA | miR-221-3p | Breast CA cells | Targeting PIK3R1 through the PI3K/AKT | ↑resistance | [109] |
| Breast CA | miR-155 | Breast CA cells | N/A | ↑resistance | [110] |
| Ovarian CA | miR-221-3p | Ovarian CA cells | Inhibiting CDKN1B | ↑progression and ↓prognosis | [48] |
| Ovarian CA | miR-141-3p | Endothelial cells | Raising VEGFR-2 expression | ↑migration and angiogenesis | [49] |
| Ovarian CA | miR-205 | Endothelial cells | PTEN-AKT | ↑angiogenesis and metastasis | [50] |
| Ovarian CA | miR21 | Ovarian CA cells | Combinng with APAF1 | ↓apoptosis | [51] |
| Ovarian CA | miR-29a-3p and miR-21-5 | CD4+ T cells | Suppressing STAT3 and regulating Treg/Th17 cells | ↑progression and metastasis | [94] |
| Ovarian CA | miR-21-3p, miR-21-5p and miR-891-5p | Ovarian CA cells | Upregulating detoxification metabolic pathways and DNA repair mechanisms | ↑resistance | [112] |
| Ovarian CA | miR-223 | Hypoxic macrophages | PTEN-PI3K/AKT | ↑resistance | [114] |
| Ovarian CA | miR-1246 | Ovarian CA cells | Targeting Cav1 | ↑resistance | [117] |
| Ovarian CA | miR-98-5p | Ovarian CA cells | Inhibiting CDKN1A expression | ↑resistance | [118] |
| Ovarian CA | miR-199a-3p | Ovarian CA cells | Inhibiting the expression of C-Met | ↓proliferation and invasion | [125] |
| Cervical CA | miR-221-3p | Endothelial cells | Regulating MAPK10 | ↑proliferation, invasion, migration and angiogenesis | [53] |
| Cervical CA | miR-221-3p | Endothelial cells | Down-regulating THBS2 | ↑angiogenesis | [54] |
| Cervical CA | miR-155-5p | Cervical CA cells | Secreting pro-inflammatory cytokines (including IL-6 and IL-8) | ↑malignancy | [55] |
| Endometrial CA | miR-133a | Endometrial CA cells | Down-regulating FOXL2 | ↑progression | [57] |
| Endometrial CA | miR-148b | Endometrial CA cells | Binding to its downstream target gene DNMT1 | ↓metastasis | [59] |
| Endometrial CA | miR-320a | Endometrial CA cells | Down-regulating HIF1 by miR-320a, leading to decreased expression of VEGFA | ↓proliferation | [128] |