Table 3.
Overview of Exosomal lncRNAs, circRNAs, DNAs and Functions in Female Reproductive System Cancer and Breast Cancers
| Cancer | lncRNA/circRNA/DNA | Recipient Cell | Pathway | Function | Reference |
|---|---|---|---|---|---|
| Breast CA | lncRNA H19 | Breast CA cells | N/A | Biomarker | [60] |
| Breast CA | lncRNA HOTAIR | Breast CA cells | N/A | Poor neoadjuvant chemotherapy and response to tamoxifen therapy | [65] |
| Breast CA | lncRNA SNHG16 | Breast CA cells | SNHG16/miR-16-5p/SMAD5/CD73 | Therapy | [90] |
| Breast CA | lnc RNA AFAP1-AS1 | Breast CA cells | Binding to AU binding factor 1 (AUF1) and promoting ERBB2 translation | ↑trastuzumab resistance | [108] |
| Breast CA | lncRNA-SNHG14 | Breast CA cells | N/A | ↑resistance | [111] |
| Ovarian CA | lncRNA FAL1 | Ovarian CA cells | Inhibiting the PTEN/AKT | ↓metastasis | [66] |
| Ovarian CA | lncRNA aHIF | Ovarian CA cells | N/A | Biomarker | [67] |
| Ovarian CA | lncRNA MALAT1 | Human umbilical vein endothelial cells | Affecting angiogenesis(VEGF-A, VEGF-D, ENA-78, PlGF, IL-8, angiogenin, bFGF and leptin) | Inhibiting the activity of caspase-3 and affecting apoptosis-related proteins | [69] |
| Ovarian CA | lncRNA UCA1 | Ovarian CA cells | inhibiting UCA1 to promote the expression of miR-143 and regulate the expression of FOSL2 | ↑resistance | [115] |
| Ovarian CA | circPUM1 | Peritoneal mesothelial cells | Upregulating the expression of NF-kB and MMP2 by spongizing miR-615-5p and miR-6753-5p | ↑proliferation, migration and invasion | [76] |
| Ovarian CA | wb-mtDNA | Ovarian CA cells | N/A | ↑progression | [82] |
| Cervical CA | LncRNA-EXOC7 | Cervical CA cells | N/A | Important biomarkers for diagnosis, evaluation of efficacy and detection of recurrence | [70] |
| Cervical CA | lncRNA HOTAIR, lncRNA MALAT1 and lncRNA MEG3 | Cervical CA cells | N/A | Biomarker | [71] |
| Cervical CA | lncRNA TUG1 | Cervical CA cells | N/A | ↑proliferation and ↓apoptosis | [72] |
| Cervical CA | lncRNA TUG1 | Cervical CA cells | Inhibiting the activity of caspase-3 and affecting apoptosis-related proteins | ↑angiogenesis | [73] |
| Cervical CA | lncRNA HNF1A-AS1 | DDP-resistant cells | Acting as the competitive endogenous RNA (ceRNA) of miR-34b, promoting the expression of TUFT1 | ↑resistance | [119] |
| Cervical CA | hsa-circRNA-0005795 and hsa-circRNA-0088088 | Cervical CA cells | N/A | improve the diagnosis and therapy | [75] |
| Cervical CA | circEIF4G2 | Cervical CA cells | N/A | biomarker | [77] |
| Cervical CA | ATF1 and RAS | Cervical CA cells | N/A | biomarker | [79] |