Table 2.

Univariate and Multivariate Analysis of Different Prognostic Parameters in Patients with HCC Patients

Factors	OS				TTR
	Univariate	Multivariate			Univariate	Multivariate
	P	HR	95% CI	P	P	HR	95% CI	P
Sex: male vs female	0.374	1.262	NA	0.373	0.974	NA	NA	0.730
Age: ≤ 50 vs > 50	0.742	NA	NA	0.804	0.469	NA	NA	0.910
HBsAg: negative vs positive	0.897	NA	NA	0.200	0.637	NA	NA	0.121
Serum AFP (ng/mL): ≤ 20 vs > 20	0.051	2.331	1.526–3.561	<0.001*	0.053	1.882	1.325–2.674	<0.001*
Liver cirrhosis: no vs yes	0.797	1.540	1.025–2.315	0.038*	0.891	1.619	1.129–2.320	0.009*
TNM: I vs II vs III–IV	0.005*	1.856	1.410–2.441	<0.001*	0.001*	1.871	1.460–2.397	<0.001*
Child-Pugh: A vs B	0.068	NA	NA	0.533	0.973	NA	NA	0.641
Tumor size: ≤ 5 cm vs > 5 cm	<0.001*	2.992	2.038–4.394	<0.001*	<0.001*	2.387	1.712–3.311	<0.001*
Tumor number: single vs multiple	0.036*	2.233	1.525–3.269	<0.001*	0.119	2.397	1.696–3.388	<0.001*
tumor differentiation: well vs moderate vs poor	0.548	NA	NA	0.072	0.454	1.900	1.089–3.317	0.024*
vascular invasion: no vs yes	0.009	1.665	1.138–2.435	0.009*	0.001*	1.588	1.137–2.217	0.007*
HSF1 expression	0.010*	1.730	1.182–2.532	0.005*	0.191	1.661	1.171–2.357	0.004*
LRP1B expression	0.028*	1.686	1.153–2.467	0.007*	0.036*	1.514	1.089–2.105	0.014*
HSF1/LRP1Bcomgination: low vs High	0.014*	1.317	1.121–1.549	0.001*	0.066	1.261	1.093–1.456	0.002*

Note: *P < 0.05 shown in bold means statistical significance.

Abbreviations: OS, cumulation overall survival; TTR, time to recurrence; HR, hazard ratio; CI, confidence interval; NA, not adopted.