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. 2020 Dec 12;11(12):1055. doi: 10.1038/s41419-020-03257-4

Fig. 2. AC007271.3 interacts with mature miR-125b-2-3p and destabilizes the pri-miR-125b-2 transcript.

Fig. 2

a Levels of pri-miR-125b-2 after overexpressing AC007271.3 in SCC9 and SCC15. b Levels of pri-miR-125b-2 after knocking down AC007271.3 in SCC9 and SCC15. c–d Stability of the pri-miR-125b-2-3p mRNA after AC007271.3 overexpression were examined at different times (0 h, 2 h, 4 h, 6 h, 8 h) after treating with actinomycin D (5 μg/mL) in SCC9 and SCC15. e MiR-125b-2-3p overexpression reduced the relative luciferase activity in AC007271.3-WT but not in AC007271.3-MUT. f RNA pulldown assay indicated the direct interaction between miR-125b-2-3p and AC007271.3 in SCC9. *p < 0.05, **p < 0.01, ***p < 0.001.