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. 2020 Dec 12;11(12):1055. doi: 10.1038/s41419-020-03257-4

Fig. 4. Slug was a target gene of miR-125b-2-3p and positively correlated with the malignancy of OSCC.

Fig. 4

a MiR-125b-2-3p overexpression reduced the relative luciferase activity in Slug-WT. b Overexpressing or inhibiting miR-125b-2-3p changed the expression of Slug protein in SCC9 (left) and SCC15(right). c The expression of Slug in OSCC (n = 319) and normal (n = 32) tissues in TCGA database. d Kaplan–Meier analysis were employed to estimate the relation between Slug expression and overall survival of OSCC patients. e Representative images of Slug expression in the OSCC tumor and adjacent non-malignant tissue analyzed by immunohistochemical. f After transfecting si-Slug in SCC9 and SCC15, the expression of Slug, E-cadherin, N-cadherin, vimentin, and β-catenin was detected by western blot. g Si-Slug inhibited the migration(left) and invasion(right) in SCC9 and SCC15. *p < 0.05, **p < 0.01, ***p < 0.001.