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. 2020 Dec 11;3:780. doi: 10.1038/s42003-020-01526-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The appearance time of IgA, IgM, IgG and total neutralizing antibodies (NAbs) between mild/moderate and severe cases. The onset time of anti-SARS-CoV-2 antibodies against nucleocapsid (N), and spike (S) proteins, anti-receptor binding domain (RBD) IgM and IgG, and NAbs against SARS-CoV-2 in mild/moderate (M) and severe (S) patients is indicated. b The optical density (OD) value of IgA, IgM and IgG antibodies against SARS-CoV-2-N, S and RBD are shown while the NAbs titers showed by geometric mean titers over the time course of the disease. The sample number of mild/moderate and severe were provided. The median and quartiles were represented in the boxplots and the bars represent the maximum and minimum values.