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. 2020 Dec 11;10:22191. doi: 10.1038/s41598-020-77490-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Survivin knockdown in vivo enhances 5-FU-induced apoptosis in HT-29 tumour cells. (a) Representative images of TUNEL apoptosis assay on dissociated HT-29 xenograft tumours after in vivo treatment with chimera and 5-FU. NOD/SCID mice bearing HT-29 tumours (60 mm³) were treated intravenously with 3 injections of 2 nmol/mouse of chimera with or without 3 additional treatment of 30 mg/kg of 5-FU. Two days after the final treatment, tumours were dissociated by collagenase digestion and subjected to TUNEL apoptosis assay. (b) Percentage of apoptotic cells in treated tumours. Data shown are means ± SEM, n = 3. ****p < 0.001. NS, no statistically significant difference.