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. 2020 Dec 11;11(12):1048. doi: 10.1038/s41419-020-03224-z

Fig. 1. Exosomes of T cells exposed to anti-PD1 therapy decrease the temozolomide-induced cell death via miR-4315.

Fig. 1

A Schematic representation of T cell exposure to anti-PD1 (αPD1, Pembrolizumab, Biovision, France). B On day#14, TransAM® FKHR/FOXO1 kit (Active Motif, France) was applied to note that anti-PD-1 exposure activates FoxO1. C On day#14, RT-qPCRs were performed to show that anti-PD-1 exposure increases the exosomal level of miR-4315. D RT-qPCRs were performed to validate the miR-4315 levels in A172 cells after their exposure to indicated exosomes. E Impact of exosomal pre-treatment on the TMZ-induced apoptosis level.